The layout of the low-temperature pipeline should consider that the entire pipeline has sufficient flexibility, and make full use of the natural compensation of the pipeline. When the design temperature is very low and cannot be compensated naturally, a compensator should be set.
When arranging low-temperature pipeline valves, the vibration of the pipeline should be avoided, especially the pump, compressor and exhaust pipe. The vibration of the entire pipeline must be prevented. If there is a mechanical vibration source, vibration damping facilities should be adopted. Install elastic elements, such as corrugated compensators, to isolate vibration sources.

On the low-temperature pipeline of carbon steel and low-alloy steel, the branch pipe equipped with safety valve, exhaust pipe or blowdown valve should pay attention to whether the low-temperature liquid medium is vaporized immediately after being discharged. Condensation until it freezes, which reduces the temperature of the pipeline to a very low level, so such branch pipes should be made of austenitic stainless steel in the range that is easy to freeze, and then flanges are used to connect branch pipes of different materials.